I had a kid a few years ago with mild, transient hypogammaglobulinemia, and
found that most of the literature was about much more severe illness. This
boy had frequent OM, but not much else. His IgG was around 200.
On the advice of two experts (Fred Rosen in Boston saw the patient and I
spoke with a woman in Tennesse, perhaps, first name Rebecca, can't recall
last name, who was very cordial and helpful), he received monthly IV IgG
which brought him well up over 300. He wasn't sick so often, After age 3 he
maintained his levels over 300 without transfusions.
Interestingly, now he's 4 and badly in need of a T&A. Did lymphoid tissue
hypertrophy in a compensatory attempt?